Immunoinformatic based identification of cytotoxic T lymphocyte epitopes from the Indian isolate of SARS-CoV-2

Abstract The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has turned into a pandemic with about thirty million confirmed cases worldwide as of September 2020. Being an airborne infection, it can be catastrophic to populous countries like India. This study sets identify potential cytotoxic T lymphocyte (CTL) epitopes in the SARS-CoV-2 Indian isolate which act effective vaccine epitope candidate for majority population. immunogenicity and foreignness towards human body have studied further confirm their candidacy. top-scoring were subjected molecular docking studies interactions corresponding leukocyte antigen (HLA) system. CTL observed bind at peptide-binding groove HLA system, indicating potency candidate. candidacy was analyzed using sequence conservation dynamics simulation. identified development vaccine.